Endothelin-1-induced bronchoconstriction in asthma.

  title={Endothelin-1-induced bronchoconstriction in asthma.},
  author={George W Chalmers and Stuart A Little and Kinjal Ravjibhai Patel and Neil C Thomson},
  journal={American journal of respiratory and critical care medicine},
  volume={156 2 Pt 1},
Endothelin-1 (ET-1) has been indirectly implicated in the pathophysiology of asthma, and it is a potent bronchoconstrictor both in vitro and by inhalation in animal models in vivo. We examined the effect of inhaled ET-1 on airway tone in comparison with methacholine in eight asthmatics and five healthy volunteers in a double-blind randomized fashion. After a screening methacholine challenge each asthmatic had two ET-1 (doubling dose range, 0.96 to 15.36 nmol) and one methacholine (doubling dose… CONTINUE READING


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