Endothelin-1-induced bronchoconstriction in asthma.

@article{Chalmers1997Endothelin1inducedBI,
  title={Endothelin-1-induced bronchoconstriction in asthma.},
  author={George W Chalmers and Stuart A Little and Kinjal Ravjibhai Patel and Neil C Thomson},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={156 2 Pt 1},
  pages={382-8}
}
Endothelin-1 (ET-1) has been indirectly implicated in the pathophysiology of asthma, and it is a potent bronchoconstrictor both in vitro and by inhalation in animal models in vivo. We examined the effect of inhaled ET-1 on airway tone in comparison with methacholine in eight asthmatics and five healthy volunteers in a double-blind randomized fashion. After a screening methacholine challenge each asthmatic had two ET-1 (doubling dose range, 0.96 to 15.36 nmol) and one methacholine (doubling dose… CONTINUE READING

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Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology • 2007
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