Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6.

@article{Mcmillen1995Endothelin1II,
  title={Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6.},
  author={Marvin A Mcmillen and Marsel Huribal and Morven E Cunningham and Rukmini Kumar and Bauer E. Sumpio},
  journal={Critical care medicine},
  year={1995},
  volume={23 1},
  pages={34-40}
}
OBJECTIVE To define whether endothelin-1, a peptide produced by injured/ischemic endothelium, has any effect on monocyte intracellular calcium and the production of interleukin (IL)-1 and IL-6. DESIGN Prospective controlled laboratory study. Human monocytes from healthy donors were assayed for intracellular calcium by fluorometry and were stimulated for 24 hrs in tissue culture with purified endotoxin or endothelin. SETTING Veterans Affairs Medical Center surgical critical care basic… CONTINUE READING