Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine.

Rings of rabbit abdominal aorta were pretreated with endothelin-1 (ET-1) or vehicle and then isometric contractions to cumulative additions of 5-hydroxytryptamine (5-HT) were recorded. ET-1 at concentrations of 0.4, 1 and 2 nM produced contractions of 7, 15 and 35% of maximal potassium chloride-induced contractions, respectively. Pretreatment of aortic… CONTINUE READING