Endothelin 1 in cancer: biological implications and therapeutic opportunities

@article{Rosan2013Endothelin1I,
  title={Endothelin 1 in cancer: biological implications and therapeutic opportunities},
  author={Laura Rosan{\`o} and Francesca M. Spinella and Anna Bagnato},
  journal={Nature Reviews Cancer},
  year={2013},
  volume={13},
  pages={637-651}
}
Activation of autocrine and paracrine signalling by endothelin 1 (ET1) binding to its receptors elicits pleiotropic effects on tumour cells and on the host microenvironment. This activation modulates cell proliferation, apoptosis, migration, epithelial-to-mesenchymal transition, chemoresistance and neovascularization, thus providing a strong rationale for… CONTINUE READING