Endothelin-1 expression during early response after antigen challenge in brown-norway rats.

@article{SnchezCifuentes1998Endothelin1ED,
  title={Endothelin-1 expression during early response after antigen challenge in brown-norway rats.},
  author={M V S{\'a}nchez-Cifuentes and Maria L Rubio and Mercedes Sora Ortega and Raquel Largo and M D Gomez-Garre and Nicol{\'a}s Gonz{\'a}lez Mangado and Germ{\'a}n Peces-Barba},
  journal={Pulmonary pharmacology & therapeutics},
  year={1998},
  volume={11 2-3},
  pages={215-9}
}
The objective of this study is to investigate if endothelin-1 (ET-1) gene expression changes during the early response phase following antigen challenge. We used sensitized Brown-Norway rats known to develop an early airway response after antigen challenge. After ovalbumin challenge, sensitized rats presented an early response, characterized by an increase in pulmonary pressure (209+/-14.53%,P<0. 01) and diminished functional parameters (inspiratory capacity, forced vital capacity (FVC) and… CONTINUE READING