Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells

@article{Koda2006Endothelin1EF,
  title={Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells},
  author={Masahiko Koda and Michael Bauer and Anja Krebs and Eckhart Georg Hahn and Detlef B Schuppan and Yoshikazu Murawaki},
  journal={Comparative Hepatology},
  year={2006},
  volume={5},
  pages={5 - 5}
}
BACKGROUND In liver injury, the pool of hepatic stellate cell (HSC) increases and produces extracellular matrix proteins, decreasing during the resolution of fibrosis. The profibrogenic role of endothelin-1 (ET-1) in liver fibrosis remains disputed. We therefore studied the effect of ET-1 on proliferation, apoptosis and profibrogenic gene expression of HSCs… CONTINUE READING