Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model

Abstract

BACKGROUND The current paradigm describing asthma pathogenesis recognizes the central role of abnormal epithelial function in the generation and maintenance of the disease. However, the mechanisms responsible for the initiation of airway remodeling, which contributes to decreased lung function, remain elusive. Therefore, we aimed to determine the role of… (More)
DOI: 10.1111/all.12271

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