Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes.

@article{Kawamura2004Endothelin1dependentNF,
  title={Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes.},
  author={Teruhisa Kawamura and Koh Ono and Tatsuya Morimoto and Masaharu Akao and Eri Iwai-Kanai and Hiromichi Wada and Naoya Sowa and Toru Kita and Koji Hasegawa},
  journal={Circulation research},
  year={2004},
  volume={94 11},
  pages={1492-9}
}
Endothelin-1 (ET-1) is a potent survival factor that protects cardiac myocytes from apoptosis. ET-1 induces cardiac gene transcription and protein expression of antiapoptotic B cell leukemia-2 (bcl-2) in a calcineurin-dependent manner. A cellular target of adenovirus early region 1A (E1A) oncoprotein, p300 also activates bcl-2 transcription in cardiac myocytes and is required for their survival. p300 acts as a calcineurin-regulated nuclear factors of activated T lymphocytes (NFATc), downstream… CONTINUE READING