Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia.

@article{Capone2012Endothelin1N,
  title={Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia.},
  author={Carmen Capone and Giuseppe Faraco and Christal G Coleman and Colin N Young and Virginia M Pickel and Josef Anrather and Robin L. Davisson and C Iadecola},
  journal={Hypertension},
  year={2012},
  volume={60 1},
  pages={106-13}
}
Obstructive sleep apnea, a condition resulting in chronic intermittent hypoxia (CIH), is an independent risk factor for stroke and dementia, but the mechanisms of the effect are unknown. We tested the hypothesis that CIH increases cerebrovascular risk by altering critical mechanisms regulating cerebral blood flow thereby lowering cerebrovascular reserves. Male C57Bl6/J mice were subjected to CIH (10% O(2) for 90 seconds/room air for 90 seconds; during sleep hours) or sham treatment for 35 days… CONTINUE READING