Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts.

  title={Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts.},
  author={Jarkko Piuhola and Istv{\'a}n Szokodi and Pietari Kinnunen and Mika Ilves and Rudolf deCh{\^a}tel and Olli Vuolteenaho and Heikki Ruskoaho},
  volume={41 1},
Endothelin-1 is involved in mechanical load-induced cardiac growth processes; it also has effects on contractility. The interaction of endothelin-1 and the Frank-Starling response is unknown. The present study aimed to characterize the role of endothelin-1 in the regulation of the Frank-Starling response, one of the major mechanisms regulating cardiac contractile force, in both normal and hypertrophied hearts. Nontransgenic rat hearts and hypertrophic hearts of hypertensive double transgenic… CONTINUE READING


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