Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.

@article{Araki2000Endothelin1AA,
  title={Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.},
  author={Makoto Araki and Koji Hasegawa and Eri Iwai-Kanai and M. Fujita and Tatsuya Sawamura and Tsuyoshi Kakita and Hiromichi Wada and Tatsuya Morimoto and Shigetake Sasayama},
  journal={Journal of the American College of Cardiology},
  year={2000},
  volume={36 4},
  pages={
          1411-8
        }
}
OBJECTIVES The purpose of this study was to investigate the regulation of beta-adrenergic agonist-induced apoptosis by endothelin-1 (ET-1) in cardiac myocytes. BACKGROUND Numerous hormonal factors including norepinephrine and ET-1 are activated in patients with heart failure. These factors may be involved in the positive and negative regulation of myocardial cell apoptosis observed in failing hearts. Recently, it has been shown that norepinephrine can induce myocardial cell apoptosis via a… CONTINUE READING
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Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

  • T Sakurai, M Yanagisawa, Y Takuwa
  • Nature
  • 1990
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