Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillaries.

@article{Dehouck1997Endothelin1AA,
  title={Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillaries.},
  author={M. P. Dehouck and Patricia Vigne and G{\'e}rard Torpier and Jean Philippe Breittmayer and Rom{\'e}o Cecchelli and Christian Frelin},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1997},
  volume={17 4},
  pages={
          464-9
        }
}
Endothelial cells and pericytes are closely associated in brain capillaries. Together with astrocytic foot processes, they form the blood-brain barrier. Capillaries were isolated from bovine brain cortex. Pure populations of endothelial cells and pericytes were isolated and cultured in vitro. Polarized monolayers of endothelial cells preferentially secreted immunoreactive endothelin-1 (Et-1) at their abluminal (brain-facing) membrane. They did not express receptors for Et-1. Pericytes expressed… CONTINUE READING
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