Endothelin 1 and thrombin synergistically stimulate IL-6 mRNA expression and protein production in human umbilical vein endothelial cells.

@article{Stankova1995Endothelin1A,
  title={Endothelin 1 and thrombin synergistically stimulate IL-6 mRNA expression and protein production in human umbilical vein endothelial cells.},
  author={Jana Stankova and Marek Rola-Pleszczynski and Pedro D'Orl{\'e}ans-Juste},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 Suppl 3},
  pages={
          S505-7
        }
}
We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation of HUVECs with ET-1 together with thrombin produced an 18-fold increase in IL-6 production. The ET-1-induced increase was concentration-dependent, with an optimal effect at 100 pM… CONTINUE READING
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