Endothelin-1 and nitric oxide in the pathogenesis of urinary tract disorders secondary to bladder outlet obstruction.

@article{Khan2003Endothelin1AN,
  title={Endothelin-1 and nitric oxide in the pathogenesis of urinary tract disorders secondary to bladder outlet obstruction.},
  author={Masood Ahmed Khan and Cecil Stanley Thompson and Michael Richard Dashwood and Faiz Mumtaz and Robert Joseph Morgan and Dimitri P. Mikhailidis},
  journal={Current vascular pharmacology},
  year={2003},
  volume={1 1},
  pages={27-31}
}
Bladder outlet obstruction (BOO) is a common disorder that is associated with urinary tract symptoms. Nitric oxide (NO), synthesized by NO synthase (NOS) is a potent vasodilator that is present throughout the urinary tract and the corpus cavernosum. Endothelin-1 (ET-1) conversely is a potent vasoconstrictor peptide that is similarly distributed throughout the urinary tract. ET-1 and NO as well as possessing opposing actions regulate each other's synthesis. The disruption of the balance between… CONTINUE READING

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