Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.


The mast cell-derived serine protease chymase is importantly involved not only in degradation, but in synthesis of bioactive peptides as well. Several studies suggest that chymase is the predominant enzyme in the production of angiotensin II (Ang II) from angiotensin-I in interstitial tissues. Interestingly, chymase has also been suggested to mature… (More)
DOI: 10.1016/j.vph.2008.06.007


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