Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.

  title={Endothelin-1 (1-31): from chymase-dependent synthesis to cardiovascular pathologies.},
  author={Pedro D'Orl{\'e}ans-Juste and Martin Houde and Giles Alexander Rae and Ghassan B Bkaily and Ewa K Carrier and {\'E}lie Simard},
  journal={Vascular pharmacology},
  volume={49 2-3},
The mast cell-derived serine protease chymase is importantly involved not only in degradation, but in synthesis of bioactive peptides as well. Several studies suggest that chymase is the predominant enzyme in the production of angiotensin II (Ang II) from angiotensin-I in interstitial tissues. Interestingly, chymase has also been suggested to mature endothelin-1 (ET-1) from its precursor, big-ET-1 in vitro. The lack of availability of specific chymase inhibitors, beyond the chymotrypsin-like… CONTINUE READING


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