Endothelin-1: a scientist's curiosity, or a real player in ischemic heart disease?

@article{Cesari1996Endothelin1AS,
  title={Endothelin-1: a scientist's curiosity, or a real player in ischemic heart disease?},
  author={Maurizio Cesari and Enrique Pav{\'a}n and Alfredo Sacchetto and Gian Paolo Rossi},
  journal={American heart journal},
  year={1996},
  volume={132 6},
  pages={1236-43}
}
Endothelin-1, the most potent endothelium-derived vasoconstrictor peptide identified so far, exerts multiple biologic effects that are potentially relevant for the pathogenesis of coronary atherosclerosis and ischemic heart disease. Since the discovery of the peptide, a good deal of experimental and clinical data have been accumulated to support an important role of endothelin-1 in ischemic heart disease. In experimental animals, exogenous endothelin-1 was found to cause coronary… CONTINUE READING

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