Endothelin: 20 years from discovery to therapy.

  title={Endothelin: 20 years from discovery to therapy.},
  author={Matthias Barton and Masashi Yanagisawa},
  journal={Canadian journal of physiology and pharmacology},
  volume={86 8},
Since its identification as an endothelial cell-derived vasoconstrictor peptide in 1988, endothelin-1, the predominant member of the endothelin peptide family, has received considerable interest in basic medical science and in clinical medicine, which is reflected by more than 20 000 scientific publications on endothelin research in the past 20 years. The story of endothelin is unique as the gene sequences of endothelin receptors and the first receptor antagonists became available within only 4… CONTINUE READING
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