Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells.

@article{Zeidel1989EndothelinAP,
  title={Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells.},
  author={Mark Lawrence Zeidel and Hugh R. Brady and Bruce C. Kone and Steven R. Gullans and Barry M. Brenner},
  journal={The American journal of physiology},
  year={1989},
  volume={257 6 Pt 1},
  pages={C1101-7}
}
Endothelin, a potent vasoconstrictor released by vascular endothelial cells, can induce natriuresis in vivo. These studies examined the regulation of Na+ transport by endothelin in suspensions of rabbit proximal tubule (PT) and inner medullary collecting duct (IMCD) cells. Endothelin reduced oxygen consumption (QO2) by 18 +/- 1% in IMCD cells but did not alter QO2 in PT cells. In IMCD cells, endothelin inhibited QO2 half maximally at approximately 5 x 10(-12) M. Several lines of evidence… CONTINUE READING

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Endothelin , a potent vasoconstrictor released by vascular endothelial cells , can induce natriuresis in vivo .
Endothelin , a potent vasoconstrictor released by vascular endothelial cells , can induce natriuresis in vivo .
Endothelin , a potent vasoconstrictor released by vascular endothelial cells , can induce natriuresis in vivo .
Endothelin , a potent vasoconstrictor released by vascular endothelial cells , can induce natriuresis in vivo .
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