Endothelial von Willebrand factor regulates angiogenesis.

  title={Endothelial von Willebrand factor regulates angiogenesis.},
  author={Richard D. Starke and Francesco Ferraro and Koralia E Paschalaki and Nicola H. Dryden and Thomas A. J. McKinnon and Rachel E Sutton and Elspeth M. Payne and Dorian O. Haskard and Alun D. Hughes and Daniel F Cutler and Mike A. Laffan and Anna M Randi},
  volume={117 3},
The regulation of blood vessel formation is of fundamental importance to many physiological processes, and angiogenesis is a major area for novel therapeutic approaches to diseases from ischemia to cancer. A poorly understood clinical manifestation of pathological angiogenesis is angiodysplasia, vascular malformations that cause severe gastrointestinal bleeding. Angiodysplasia can be associated with von Willebrand disease (VWD), the most common bleeding disorder in man. VWD is caused by a… CONTINUE READING
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