Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy.

@article{Sorrentino2010EndothelialvasoprotectiveEO,
  title={Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy.},
  author={Sajoscha A. Sorrentino and Christian Besler and Lucia Rohrer and Martin Meyer and Kathrin Heinrich and Ferdinand Hermann Bahlmann and Maja Franziska M{\"u}ller and Tibor Horv{\'a}th and Carola Doerries and Mariko Heinemann and Stella Flemmer and Andrea Markowski and Costantina Manes and Matthias J. Bahr and Hermann Haller and Arnold von Eckardstein and Helmut Drexler and Ulf Landmesser},
  journal={Circulation},
  year={2010},
  volume={121 1},
  pages={110-22}
}
BACKGROUND High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared the endothelial effects of HDL from healthy subjects and from patients with type 2 diabetes mellitus and low HDL (meeting the criteria for metabolic syndrome), who are frequently considered for HDL-raising therapies. Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the… CONTINUE READING