Endothelial vascular toxicity from chemotherapeutic agents: preclinical evidence and clinical implications.

@article{Soultati2012EndothelialVT,
  title={Endothelial vascular toxicity from chemotherapeutic agents: preclinical evidence and clinical implications.},
  author={Aspasia S Soultati and Giannis Mountzios and Chrysoula Avgerinou and George Papaxoinis and Dimitrios G Pectasides and Meletios Athanasios Dimopoulos and Christos Papadimitriou},
  journal={Cancer treatment reviews},
  year={2012},
  volume={38 5},
  pages={473-83}
}
In cancer biology angiogenesis plays a vital role in tumour growth and its subsequent metastatic potential. By targeting the angiogenic process, a new treatment strategy was added in the clinician's therapeutic armamentarium. On the other hand, numerous classic cytotoxic agents are currently considered as potential angiogenesis inhibitors, although they were not originally developed as such, representing the so-called "accidental" anti-angiogenic drugs. The discovery of these new properties of… CONTINUE READING