Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma.

@article{Leventhal1999EndothelialTS,
  title={Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma.},
  author={Caroline Leventhal and Shahin Rafii and Dahlia Rafii and Abraham Shahar and Steven A Goldman},
  journal={Molecular and cellular neurosciences},
  year={1999},
  volume={13 6},
  pages={450-64}
}
Vascular endothelial cells are among the first cells that ventricular zone neuroblasts encounter during early development. The ventricular zone cells promote angiogenesis by the invading vasculature, with the release of endothelial mitogens. Yet the feedback support of young neurons by endothelial cells (ECs) has not hitherto been explored. We therefore asked whether ECs might participate in neuronal recruitment, by providing neurotrophic support to newly generated neurons. We used the… CONTINUE READING
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