Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.

Abstract

Endothelial cells (ECs) not only are important for oxygen delivery but also act as a paracrine source for signals that determine the balance between tissue regeneration and fibrosis. Here we show that genetic inactivation of flow-induced transcription factor Krüppel-like factor 2 (KLF2) in ECs results in reduced liver damage and augmentation of hepatocyte… (More)
DOI: 10.1073/pnas.1613392114

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