Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension.

@article{Kitao2009EndothelialTM,
  title={Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension.},
  author={Azusa Kitao and Yasunori Sato and Seiko Sawada-Kitamura and Kenichi Harada and Motoko Sasaki and Hiroyasu Morikawa and Susumu Shiomi and Masao Honda and Osamu Matsui and Yasuni Nakanuma},
  journal={The American journal of pathology},
  year={2009},
  volume={175 2},
  pages={616-26}
}
Idiopathic portal hypertension (IPH) represents noncirrhotic portal hypertension of unknown etiology, mainly due to stenosis of peripheral portal veins. This study was performed to clarify the mechanism of portal venous stenosis in IPH from the viewpoint of the contribution of the endothelial to mesenchymal transition of the portal vein endothelium via transforming growth factor-beta1 (TGF-beta1)/Smad activation. In vitro experiments using human dermal microvascular endothelial cells… CONTINUE READING

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