Endothelial-to-mesenchymal transition drives atherosclerosis progression.

@article{Chen2015EndothelialtomesenchymalTD,
  title={Endothelial-to-mesenchymal transition drives atherosclerosis progression.},
  author={Pei-Yu Chen and L. Qin and Nicolas Baeyens and Guangxin Li and T. Afolabi and Madhusudhan Budatha and G. Tellides and M. Schwartz and M. Simons},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 12},
  pages={
          4514-28
        }
}
The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelial FGFR1 expression and activated TGF-β signaling. We further explored the link between disrupted FGF… Expand
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