Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway.

@article{Curci2014EndothelialtomesenchymalTA,
  title={Endothelial-to-mesenchymal transition and renal fibrosis in ischaemia/reperfusion injury are mediated by complement anaphylatoxins and Akt pathway.},
  author={Claudia Curci and Giuseppe Castellano and Alessandra Stasi and Chiara Divella and Antonia Loverre and Margherita Gigante and Simona Simone and Marica Cariello and Vincenzo Montinaro and Giuseppe Lucarelli and Pasquale Ditonno and Michele Battaglia and Antonio Crovace and Francesco Staffieri and Beatrijs D Oortwijn and Edwin S. van Amersfoort and Loreto Gesualdo and Giuseppe Grandaliano},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2014},
  volume={29 4},
  pages={799-808}
}
BACKGROUND Increasing evidence demonstrates a phenotypic plasticity of endothelial cells (ECs). Endothelial-to-mesenchymal transition (EndMT) contributes to the development of tissue fibrosis. However, the pathogenic factors and signalling pathways regulating this process in ischaemia/reperfusion (I/R) injury are still poorly understood. METHODS We investigated the possible role of complement in the induction of this endothelial dysfunction in a swine model of renal I/R injury by using… CONTINUE READING
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