Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.

  title={Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.},
  author={Ampadu O. Jackson and Jingjing Zhang and Z. Jiang and K. Yin},
  journal={Trends in cardiovascular medicine},
  volume={27 6},
  • Ampadu O. Jackson, Jingjing Zhang, +1 author K. Yin
  • Published 2017
  • Biology, Medicine
  • Trends in cardiovascular medicine
  • Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of… CONTINUE READING
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