Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.

@article{Jackson2017EndothelialtomesenchymalTA,
  title={Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.},
  author={Ampadu O. Jackson and Jingjing Zhang and Z. Jiang and K. Yin},
  journal={Trends in cardiovascular medicine},
  year={2017},
  volume={27 6},
  pages={
          383-393
        }
}
  • Ampadu O. Jackson, Jingjing Zhang, +1 author K. Yin
  • Published 2017
  • Biology, Medicine
  • Trends in cardiovascular medicine
  • Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of… CONTINUE READING
    40 Citations

    Tables and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad.
    A Computational Model of the Endothelial to Mesenchymal Transition
    • 4
    • Highly Influenced
    • PDF
    TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases
    • 86
    • PDF
    Non-coding RNA in endothelial-to-mesenchymal transition
    • 2
    • PDF
    Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy
    • 4

    References

    SHOWING 1-10 OF 137 REFERENCES
    Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases
    • 70
    Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders.
    • 396
    Endothelial-Mesenchymal Transition in Regenerative Medicine
    • D. Medici
    • Biology, Medicine
    • Stem cells international
    • 2016
    • 41
    • PDF
    Endothelial-to-mesenchymal transition drives atherosclerosis progression.
    • 197
    • Highly Influential
    • PDF
    The role of endothelial–mesenchymal transition in development and pathological process
    • 127
    Endothelial to mesenchymal transition contributes to arsenic-trioxide-induced cardiac fibrosis
    • 31
    • PDF
    Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • 1,574
    • PDF
    Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
    • 176
    • Highly Influential
    • PDF