Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.

  title={Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases.},
  author={Ampadu O. Jackson and Jingjing Zhang and Zhisheng Jiang and Kai Yin},
  journal={Trends in cardiovascular medicine},
  volume={27 6},
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications referenced by this paper.
Showing 1-10 of 123 references

Matrix metalloproteinase 9-dependent Notch signaling contributes to kidney fibrosis through peritubular endothelial–mesenchymal transition

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2017
View 18 Excerpts
Highly Influenced

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

The Journal of clinical investigation • 2015
View 4 Excerpts
Highly Influenced

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Drug design, development and therapy • 2015
View 15 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…