Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124.

@article{Simone2012EndothelialTO,
  title={Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124.},
  author={Eric A. Simone and Blaine Zern and A Chacko and John L. Mikitsh and Eric R Blankemeyer and Silvia Muro and Radu V Stan and Vladimir R Muzykantov},
  journal={Biomaterials},
  year={2012},
  volume={33 21},
  pages={5406-13}
}
Targeting of therapeutics or imaging agents to the endothelium has the potential to improve specificity and effectiveness of treatment for many diseases. One strategy to achieve this goal is the use of nanoparticles (NPs) targeted to the endothelium by ligands of protein determinants present on this tissue, including cell adhesion molecules, peptidases, and cell receptors. However, detachment of the radiolabel probes from NPs poses a significant problem. In this study, we devised polymeric NPs… CONTINUE READING

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