Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis.

@article{Bauer2005EndothelialspecificEO,
  title={Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis.},
  author={Philip M. Bauer and Jun Yu and Yan Chen and Reed Hickey and Pascal Bernatchez and Robin C Looft-Wilson and Yan Huang and Frank Giordano and Radu V Stan and William C Sessa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 1},
  pages={204-9}
}
The functions of caveolae and/or caveolins in intact animals are beginning to be explored. Here, by using endothelial cell-specific transgenesis of the caveolin-1 (Cav-1) gene in mice, we show the critical role of Cav-1 in several postnatal vascular paradigms. First, increasing levels of Cav-1 do not increase caveolae number in the endothelium in vivo. Second, despite a lack of quantitative changes in organelle number, endothelial-specific expression of Cav-1 impairs endothelial nitric oxide… CONTINUE READING