Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion.

@article{Chadjichristos2010EndothelialspecificDO,
  title={Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion.},
  author={Christos Evangelos Chadjichristos and K E Ludwig Scheckenbach and Toon A. B. van Veen and M Z Richani Sarieddine and Cor de Wit and Zhengqin Yang and Isabelle Roth and Matthew D. Bacchetta and Hema Viswambharan and Bernard F Foglia and Tecla S Dudez and Marjan van Kempen and Frank E J Coenjaerts and Lucile Miquerol and Urban Deutsch and Habo J. Jongsma and Marc Chanson and Brenda R Kwak},
  journal={Circulation},
  year={2010},
  volume={121 1},
  pages={123-31}
}
BACKGROUND Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis. In the present report, we sought to determine whether Cx40 contributes to the development of the disease. METHODS AND RESULTS Mice with ubiquitous deletion of Cx40 are… CONTINUE READING