Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons.

  title={Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons.},
  author={Qiang Shi and Gene B. Hubbard and Rampratap S. Kushwaha and David Rainwater and Charles A. Thomas and M. Michelle Leland and John L Vandeberg and Xing Li Wang},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={292 6},
Increasing evidence indicates that replicative senescence and premature endothelial senescence could contribute to endothelial dysfunction. This study aims at testing the hypothesis that a high-fat diet may lead to premature vascular endothelial senescence in a nonhuman primate model. We isolated endothelial cells from left and right femoral arteries in 10 baboons before and after a 7-wk high-fat dietary treatment. We compared the morphological alterations, replicative capacities, and… CONTINUE READING
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