Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.

@article{Laursen2001EndothelialRO,
  title={Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.},
  author={J\orn Bech Laursen and Michael Somers and Stefan Kurz and L Mccann and Ascan Warnholtz and Bruce A. Freeman and Margaret M Tarpey and Tohru Fukai and David G Harrison},
  journal={Circulation},
  year={2001},
  volume={103 9},
  pages={1282-8}
}
BACKGROUND Altered endothelial cell nitric oxide (NO(*)) production in atherosclerosis may be due to a reduction of intracellular tetrahydrobiopterin, which is a critical cofactor for NO synthase (NOS). In addition, previous literature suggests that inactivation of NO(*) by increased vascular production superoxide (O(2)(*-)) also reduces NO(*) bioactivity in several disease states. We sought to determine whether these 2 seemingly disparate mechanisms were related. METHODS AND RESULTS… CONTINUE READING
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