Endothelial proteoglycans inhibit bFGF binding and mitogenesis.

  title={Endothelial proteoglycans inhibit bFGF binding and mitogenesis.},
  author={Kimberly E. Forsten and N A Courant and Matthew A. Nugent},
  journal={Journal of cellular physiology},
  volume={172 2},
Basic fibroblast growth factor (bFGF) is a known mitogen for vascular smooth muscle cells and has been implicated as having a role in a number of proliferative vascular disorders. Binding of bFGF to heparin or heparan sulfate has been demonstrated to both stimulate and inhibit growth factor activity. The activity, towards bFGF, of heparan sulfate proteoglycans present within the vascular system is likely related to the chemical characteristics of the glycosaminoglycan as well as the structure… CONTINUE READING