Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor.

@article{Feistritzer2006EndothelialPC,
  title={Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor.},
  author={Clemens Feistritzer and Birgit A. Mosheimer and Daniel H. Sturn and Matthias Riewald and Josef R. Patsch and Christian J Wiedermann},
  journal={Journal of immunology},
  year={2006},
  volume={176 2},
  pages={
          1019-25
        }
}
The protein C pathway is an important regulator of the blood coagulation system. Protein C may also play a role in inflammatory and immunomodulatory processes. Whether protein C or activated protein C affects lymphocyte migration and possible mechanisms involved was tested. Lymphocyte migration was studied by micropore filter assays. Lymphocytes that were pretreated with protein C (Ceprotin) or activated protein C (Xigris) significantly reduced their migration toward IL-8, RANTES, MCP-1, and… CONTINUE READING

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