Endothelial progenitor cells as a new cardiovascular risk factor in Klinefelter's syndrome.

@article{Mambro2010EndothelialPC,
  title={Endothelial progenitor cells as a new cardiovascular risk factor in Klinefelter's syndrome.},
  author={Antonella Di Mambro and Alberto Ferlin and Luca De Toni and Riccardo Selice and Nicola Caretta and C Foresta},
  journal={Molecular human reproduction},
  year={2010},
  volume={16 6},
  pages={411-7}
}
Klinefelter syndrome (KS) is associated with a significant reduced life expectancy (2.1 years) including greater mortality from cardiovascular diseases. Underlying causes that may involve low levels of testosterone as well as the extra X chromosome are not fully understood. Low testosterone may have a direct affect on vascular tissue or act indirectly via metabolic effects. Testosterone levels may act genomically on cardiac function via the androgen receptor (AR) or non-genomically. Recently… CONTINUE READING

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