Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy.

@article{Liu2010EndothelialPC,
  title={Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopathy.},
  author={Xialin Liu and Yongjun Li and Yizhi Liu and Yan Luo and Dingding Wang and Brian Herb Annex and Pascal J. Goldschmidt-Clermont},
  journal={The American journal of pathology},
  year={2010},
  volume={176 1},
  pages={504-15}
}
Diabetic retinopathy is characterized by pathological retinal neovascularization. Accumulating evidence has indicated that high levels of circulating endothelial progenitor cells (EPCs) are an important risk factor for neovascularization. Paradoxically, the reduction and dysfunction of circulating EPCs has been extensively reported in diabetic patients. We hypothesized that EPCs are differentially altered in the various vasculopathic complications of diabetes mellitus, exhibiting distinct… CONTINUE READING
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