Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.

@article{Deregibus2007EndothelialPC,
  title={Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.},
  author={Maria Chiara Deregibus and Vincenzo Cantaluppi and Raffaele Calogero and Marco Lo Iacono and Ciro Tetta and Luigi Biancone and Stefania Bruno and Benedetta Bussolati and Giovanni Camussi},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={2440-8}
}
Membrane-derived microvesicles (MVs) are released from the cell surface and are implicated in cell-to-cell communication. We evaluated whether MVs derived from endothelial progenitor cells (EPCs) are able to trigger angiogenesis. We found that EPC-derived MVs were incorporated in endothelial cells by interaction with alpha4 and beta1 integrins expressed on… CONTINUE READING