Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease.

@article{Coleman2004EndothelialPC,
  title={Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease.},
  author={Harold Arthur Coleman and Marianne Tare and Helena C Parkington},
  journal={Clinical and experimental pharmacology & physiology},
  year={2004},
  volume={31 9},
  pages={641-9}
}
1. The elusive nature of endothelium-derived hyperpolarizing factor (EDHF) has hampered detailed study of the ionic mechanisms that underlie the EDHF hyperpolarization and relaxation. Most studies have relied on a pharmacological approach in which interpretations of results can be confounded by limited specificity of action of the drugs used. Nevertheless, small-, intermediate- and large-conductance Ca2+-activated K+ channels (SKCa, IKCa and BKCa, respectively) have been implicated, with inward… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 111 references

284-9

  • Coleman HA Parkington HC. Regulation of vascular smooth mu Tare M, in diabetes . Neurophys.2003, 35
  • Recei ved 10 December 2003, in re vised form 25…
  • 2004

Developmental changes in myoendothelial g ap junction mediated v asodilator activity in the rat saphenous artery

  • SL Sando w, K Goto, NM Rummery, CE. Hill
  • J Physiol.2004;556:
  • 2004

H1527-34

  • Esser N Lehr H Bolz S Pohl U. Pentobarbital-sensiti ve E De Wit C, 276
  • Proceedings of the Australian Physiological and…
  • 2004

Ouabain e xerts biphasic ef fects on connexin functionality and e xpression in v ascular smooth muscle cells

  • PEM Martin, NS Hill, B Kristensen, RJ Errington, TM. Griffith
  • Br. J. Pharmacol.2004;
  • 2004

Endothelium-deri ved hyperpolarizing f actor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes Proceedings of the Australian Physiological and Pharmacological Society

  • ArcherSL, FS Gragasin, X Wu, S Wang, S McMurtry, DH Kim
  • BK Ca channels. Circ
  • 2003

Similar Papers

Loading similar papers…