Endothelial permeability is increased by the supernatant of peripheral blood mononuclear cells stimulated with HLA Class II antibody.

@article{Wakamoto2008EndothelialPI,
  title={Endothelial permeability is increased by the supernatant of peripheral blood mononuclear cells stimulated with HLA Class II antibody.},
  author={Shinobu Wakamoto and Mitsuhiro Fujihara and Hisako Sakagawa and Daisuke Takahashi and Koichi Niwa and Masanobu Morioka and Shinichiro Sato and Toshiaki Kato and Hiroshi Azuma and Hisami Ikeda},
  journal={Transfusion},
  year={2008},
  volume={48 10},
  pages={
          2060-8
        }
}
BACKGROUND The generation of inflammatory mediators from monocytes activated by HLA Class II antibodies is thought to play important roles in the etiology of nonhemolytic transfusion reactions. Increased permeability of endothelial cells contributes to the pathogenesis of rash, urticaria, angioedema, and pulmonary edema, which are symptoms of transfusion reactions. STUDY DESIGN AND METHODS We investigated whether inflammatory mediators released from monocytes upon stimulation by HLA Class II… CONTINUE READING
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