Endothelial-pericyte interactions in angiogenesis

  title={Endothelial-pericyte interactions in angiogenesis},
  author={Holger Gerhardt and Christer Betsholtz},
  journal={Cell and Tissue Research},
It takes two to make blood vessels—endothelial cells and pericytes. While the endothelial cells are the better characterized of the two, pericytes are now coming into focus as important regulators of angiogenesis and blood vessel function, and as potential drug targets. However, pericytes are still surrounded by much controversy. They are difficult to define, they constitute a heterogeneous population of cells, and their ontogeny is not well understood. They are plastic and have the capacity to… CONTINUE READING
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