Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells.

@article{Fron1996EndothelialNO,
  title={Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells.},
  author={Olivier F{\'e}ron and L Belhassen and Lester Kobzik and Thomas W. Smith and Ralph A. Kelly and Thomas Michel},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={22810-4}
}
The endothelial isoform of nitric oxide synthase (eNOS) modulates cardiac myocyte function and is expressed in the particulate subcellular fraction. We have previously shown that eNOS is targeted to plasmalemmal caveolae in endothelial cells. Caveolae, specialized domains of the plasma membrane, may serve to sequester signaling proteins; a family of transmembrane proteins, the caveolins, form a key structural component of these microdomains. Caveolae in cardiac tissues contain the muscle… CONTINUE READING

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