Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells.

@article{Ibiza2008EndothelialNO,
  title={Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells.},
  author={Sales Ibiza and Andrea P{\'e}rez-Rodr{\'i}guez and Angel Ortega and Antonio Mart{\'i}nez-Ruiz and Olga Barreiro and Carlota A. Garc{\'i}a-Dom{\'i}nguez and Victor M Victor and Juan V Esplugues and Jos{\'e} Mar{\'i}a Rojas and Francisco S{\'a}nchez-Madrid and Juan M Serrador},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 30},
  pages={
          10507-12
        }
}
Ras/ERK signaling plays an important role in T cell activation and development. We recently reported that endothelial nitric oxide synthase (eNOS)-derived NO regulates T cell receptor (TCR)-dependent ERK activation by a cGMP-independent mechanism. Here, we explore the mechanisms through which eNOS exerts this regulation. We have found that eNOS-derived NO positively regulates Ras/ERK activation in T cells stimulated with antigen on antigen-presenting cells (APCs). Intracellular activation of N… CONTINUE READING

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