Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome.

@article{Monti2003EndothelialNO,
  title={Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome.},
  author={Lucilla Domenica Monti and Cristina Barlassina and Lorena Citterio and Elena Galluccio and Carlo R Berzuini and Emanuela Setola and Gianpietro Valsecchi and Pietro Lucotti and Guido Pozza and Luisa Bernardinelli and Giorgio Casari and Piermarco Piatti},
  journal={Diabetes},
  year={2003},
  volume={52 5},
  pages={1270-5}
}
Endothelial nitric oxide synthase (eNOS) variants were previously demonstrated in cardiovascular disease. To evaluate whether eNOS gene variants are associated with insulin resistance and type 2 diabetes, we evaluated polymorphisms in Exon7 (E298D), intron 18 (IVS18 + 27A-->C), and intron 23 (IVS23 + 10G-->T) in 159 type 2 diabetic patients without macrovascular complications and in 207 healthy control subjects. Samples for all hormonal and metabolic variables were obtained after an overnight… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Endothelial nitric oxide synthase gene sequence variation and vascular disease

XL Wang, J Wang
Mol Gen Metab 70:241–251, • 2000

Similar Papers

Loading similar papers…