Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage.

@article{Ko2008EndothelialNO,
  title={Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage.},
  author={Nerissa U. Ko and Pam R. Rajendran and Helen Kim and Martin J. Rutkowski and Ludmila Pawlikowska and Pui-Yan Kwok and Randall Higashida and M T Lawton and Wade S. Smith and Jonathan G. Zaroff and William L. Young},
  journal={Stroke},
  year={2008},
  volume={39 4},
  pages={1103-8}
}
BACKGROUND AND PURPOSE Vasospasm after aneurysmal subarachnoid hemorrhage (SAH) remains a leading cause of death and disability after aneurysm rupture. Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients. METHODS We conducted a prospective cohort study of SAH patients and determined vasospasm by cerebral angiography. We genotyped 3 eNOS… CONTINUE READING

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