Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.

@article{Jones2004EndothelialNO,
  title={Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.},
  author={Steven P Jones and James J. M. Greer and Aman K Kakkar and P Derek Ware and Richard H. Turnage and Michael B Hicks and Rien van Haperen and Rini de Crom and Seinosuke Kawashima and Mitsuhiro Yokoyama and David Joseph Lefer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 1},
  pages={H276-82}
}
Previous studies indicate that deficiency of endothelial nitric oxide (NO) synthase (eNOS)-derived NO exacerbates myocardial reperfusion injury. We hypothesized that overexpression of eNOS would reduce the extent of myocardial ischemia-reperfusion (MI/R) injury. We investigated two distinct strains of transgenic (TG) mice overexpressing the eNOS gene (eNOS TG). Bovine eNOS was overexpressed in one strain (eNOS TG-Kobe), whereas the human eNOS gene was overexpressed in the other strain (eNOS TG… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated nitric oxide synthase

R Van Haperen, M de Waard, +7 authors R. de Crom
J Biol Chem • 2002
View 8 Excerpts
Highly Influenced

Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice

SP Jones, JJM Greer, +3 authors DJ. Lefer
Proc Natl Acad Sci USA • 2003
View 3 Excerpts

Similar Papers

Loading similar papers…