Endothelial nitric oxide synthase modulates gastric ulcer healing in rats.

@article{Ma2000EndothelialNO,
  title={Endothelial nitric oxide synthase modulates gastric ulcer healing in rats.},
  author={Lan-fang Ma and John L Wallace},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={279 2},
  pages={G341-6}
}
Nitric oxide has been shown to be beneficial for gastric ulcer healing. We determined the relative effects of endothelial and inducible nitric oxide synthases on gastric ulcer healing in rats. Ulcers were induced by serosal application of acetic acid. Ulcer severity, angiogenesis, and nitric oxide synthase expression were assessed 3-10 days later. The effects of inhibitors of nitric oxide synthase were also examined. Inducible nitric oxide synthase mRNA was only detected in ulcerated tissue… CONTINUE READING

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