Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.

@article{ScherrerCrosbie2001EndothelialNO,
  title={Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.},
  author={Marielle Scherrer-Crosbie and Robert Ullrich and Kenneth D. Bloch and Hiroshi Nakajima and Boris A Nasseri and H. Thomas Aretz and Merry L Lindsey and Anne Claire Vançon and Paul Lee Huang and Richard T Lee and Warren M. Zapol and Michael H Picard},
  journal={Circulation},
  year={2001},
  volume={104 11},
  pages={1286-91}
}
Background- To investigate the role of endothelial nitric oxide synthase (NOS3) in left ventricular (LV) remodeling after myocardial infarction (MI), the impact of left anterior descending coronary artery ligation on LV size and function was compared in 2- to 4-month-old wild-type (WT) and NOS3-deficient mice (NOS3(-/-)). Methods and Results- Two days after MI, both strains of mice had a similar LV size, fractional shortening, and ejection fraction by echocardiography. Twenty-eight days after… CONTINUE READING

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