Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis.

@article{Bivalacqua2007EndothelialNO,
  title={Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis.},
  author={Trinity J. Bivalacqua and Tongyun Liu and B Musicki and Hunter C. Champion and Arthur L. Burnett},
  journal={European urology},
  year={2007},
  volume={51 6},
  pages={1732-40}
}
OBJECTIVES We evaluated the regulatory influence of endothelial nitric oxide (NO) on the basal functional states of the NO and RhoA/Rho-kinase signaling pathways in the penis using endothelial NO synthase (eNOS) mutant mice and eNOS gene transfer technology. METHODS Four groups of mice were used: wild type (WT), eNOS gene deleted (eNOS-/-), eNOS and neuronal NOS gene deleted (dNOS-/-), and eNOS-/- mutant mice transfected intracavernosally with eNOS. Cyclic guanosine monophosphate (cGMP… CONTINUE READING
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