Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.

@article{Yu2005EndothelialNO,
  title={Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.},
  author={Jun Yu and Ebo DeMuinck and Zhenwu Zhuang and Mary C Drinane and Katalin Kauser and Gabor M. Rubanyi and Hu Sheng Qian and Takahisa Murata and Bruno Escalante and William C Sessa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 31},
  pages={
          10999-1004
        }
}
The genetic loss of endothelial-derived nitric oxide synthase (eNOS) in mice impairs vascular endothelial growth factor (VEGF) and ischemia-initiated blood flow recovery resulting in critical limb ischemia. This result may occur through impaired arteriogenesis, angiogenesis, or mobilization of stem and progenitor cells. Here, we show that after ischemic challenge, eNOS knockout mice [eNOS (-/-)] have defects in arteriogenesis and functional blood flow reserve after muscle stimulation and… CONTINUE READING
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